![]() These results provide a pathogenesis for AA amyloidosis and suggest possible measures for rescuing cheetahs from extinction.ĪA amyloidosis, known as reactive or secondary amyloidosis, is generally recognized as the predominant form of systemic amyloidosis that occurs in domestic animals and the animal kingdom ( 3). ![]() Thus, we propose that feces are a vehicle of transmission that may accelerate AA amyloidosis in captive cheetah populations. HCl and formic acid or by AA immunodepletion.The infectious activity of fecal AA amyloid fibrils was reduced or abolished by the protein denaturants 6 M guanidine In this study of animals with AA amyloidosis, we found that cheetah feces contained AA amyloid fibrils that were different from those of the liver with regard to molecular weight and shape and had greater transmissibility. ![]() Given the transmissible characteristics of AA amyloidosis, transmission between captive cheetahs may be a possible mechanism involved in the high incidence of AA amyloidosis. AA amyloidosis is one of the principal causes of morbidity and mortality in captive cheetahs ( Acinonyx jubatus), which are in danger of extinction, but little is known about the underlying mechanisms.
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